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ObjectiveTo study the changes of cardiac autonomic nervous function and EEG non-linear dynamics character in depressive patients,and to explore the functional activity state of brain.Methods24-hour ambulatory ECG was recorded in 47 depressive patients and 47 normal control people by multi-channel ECG machine.The index of heart rate variability,the incidence of arrhythmias and the relationship between HRV and the severity of depression were analyzed.ResultsCompared with the control group,the standard deviation of NN intervals(SDNN)((91.31±15.11)ms),the standard deviation of normal number of intervals(SDANN)((82.14±16.26)ms),the root mean square of successive differences (RMSSD)((37.13±8.02)ms),the percentage of pairs of adjacent RR intervals differing by >50 ms (PNN50)(11.05±7.02) and High-frequency(HF)((17.07±4.34)ms) in depression group were lower,however low-frequency(LF)((18.27±6.32)ms) and LF/HF((1.07±0.33)ms) were higher(P<0.05).There were positive linear correlation between depression severity and LF/HF(P <0.05,r=0.332) and negative linear correlation between depression severity and SDNN(P<0.05,r=-0.296).Compared with control group,the incidence rate of arrhythmia of depressive group was increased,especially in supraventricular arrhythmias.In quiet state with eyes closed: compared with the control group,the level of correlation dimension (D2) in left occiput,left middle and behind temple region were increased in group A,but the difference was not statistically significant.In group B,except prefrontal area,the D2 of the left hemisphere were increased especially in the left central area(3.91±0.37),left parietal lobe(3.85±0.43),left occipital(4.10±0.54)and left temporal(4.20±0.61) compared with control group (P<0.01).The brain electrical activity in other areas were not found change.ConclusionThe cardiac autonomic nervous function of depressive patient is positively correlated with the the severity of depression.Depressive patients are likely to conduct supraventricular arraythmia.Left hemisphere cerebral cortex is active in depressive patients by analysing the EEG non-linear dynamics character.
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Objective To explore the features and neural generators of the events related potentials ( ERP) component N400, elicited by congruent and incongruent ending sentences, in first episode schizophrenia patients. Methods N400 was elicited by 76 congruent (31) or incongruent (45) ending Chinese sentences paradigm, and recorded by WJ-1 ERP instruments in 56 first episode schizophrenia. The neural generators of N400 different wave in 105 -615 ms time windows were analyzed by Brain Electrical Activity Mapping software. Results① The N400 latencies were significantly longer and amplitudes significantly higher in incongruent conditions than in congruent conditions in first episode schizophrenia (P < 0.05 or P <0.01).② N400 elicited by Chinese sentences distributed on frontal, parietal, occipital and temporal regions, and had a clear waveform. ③ The main brain areas activated by N400 were frontal areas in 345 -405 ms time windows, and central areas in 420 - 570 ms time windows. Conclusion N400 elicited by Chinese sentences are multi-generated in first episode schizophrenia, especially in frontal area.
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Objective:The topographical mapping technique of cortical evoked potential was used to observe the changes of the functional activities in the primary somatosensory area of cortex (SI) during external stimulation,the immanent relation between external stimulation and topographical mapping of cortical somatosensory evoked potential (CSEP). Methods:33 healthy adult volunteers were under observation. Cerebral electric signal processing system was used to lead CSEP on the scalp. The external stimulation was applied as following:①A soft paintbrush was used to slightly brush the face only. ②Paintbrush was used to slightly brush the lower limb only. ③Paintbrush was used to slightly brush the trunk only. ④Paintbrush was used to slightly brush the lower limb or the trunk or the Gallbladder Meridian (GBM) and passing the upper arm by imitating the speed of meridian transmission phenomenon respectively. Results:①Evoking responses appeared in the foot areas in SI,without meridian transmission phenomenon when brushing the face,lower limb or trunk only. ②Healthy volunteers were offered imitation of sensation conduction along the GBM as well as brushing through the upper arm in addition,while,the results showed that the evoking responses appeared in the foot,the upper arm and the face representation area of SI simultaneously. Conclusion:The external stimulation along the meridian course was able to change the distribution of evoking responses in SI during stimulating acupoint. But the local stimulating on face,lower limb or trunk can not change the distribution of CSEP. The results provided experimental evidence for the supposition that 'activation in sequence in periphery'was the decisive factor for the formation of meridian transmission phenomenon.
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3 grades on the corresponding areas with compare to normal person, the positive rate of BEAM ia patient with CVD was 90.4%, more than that of the result of routine EEG(73%).
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Changes of ABR and LEDVEP in 60 patients with mild head injury and of ABR LEDVEP BEAM in 40 out of 60 patienites were studied. The results were as folls:we:①The Chief abnormality of ABR. was the prolongation of Ⅰ- Ⅲ interpeak latency ②The appaent abnomality of the LEDVEP was the prolongation of N70 latency and the drop of N70-P100 amplitude ③The characteristic change of BEAM was the incre ment of average ?1 power. The increment of ?/?2 power ratio suggested the presence of supertentorial lesions.According to the follow up study of clectrophysiological findings, a scale of brain dysfunction was created,It provides an objective criterion for clinical diagnosis and prognostic determination. In forensic practicl. Grade O and Ⅰ could be considered as minimal wound and Grade Ⅱ as slight wound,